Allergic conjunctivitis: Ophthalmic:
0.1%: Instill 1 drop into each affected eye twice daily (allowing 6 to 8 hours between doses).
0.2%: Instill 1 drop into each affected eye once daily.
0.7%: Instill 1 drop into each affected eye once daily.
There are no dosage adjustments provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.
(For additional information see "Olopatadine (ophthalmic): Pediatric drug information")
Allergic conjunctivitis/Ocular itching:
Olopatadine 0.1%: Children ≥2 years and Adolescents: Ophthalmic: Instill 1 drop into affected eye(s) twice daily, allowing 6 to 8 hours between doses.
Olopatadine 0.2%: Children ≥2 years and Adolescents: Ophthalmic: Instill 1 drop into affected eye(s) once daily.
Olopatadine 0.7%: Children ≥2 years and Adolescents: Ophthalmic: Instill 1 drop into affected eye(s) once daily.
There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.
Refer to adult dosing.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Solution, Ophthalmic:
Pataday: 0.1% (5 mL) [contains benzalkonium chloride]
Pataday: 0.2% (2.5 mL) [contains benzalkonium chloride, edetate (edta) disodium]
Pataday: 0.7% (2.5 mL) [contains benzalkonium chloride]
Patanol: 0.1% (5 mL [DSC]) [contains benzalkonium chloride]
Pazeo: 0.7% (2.5 mL [DSC]) [contains benzalkonium chloride]
Generic: 0.1% (5 mL); 0.2% (2.5 mL)
Yes
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Ophthalmic:
Pataday: 0.2% (0.5 mL, 2.5 mL) [contains benzalkonium chloride, edetate (edta) disodium]
Patanol: 0.1% (5 mL, 10 mL, 15 mL) [contains benzalkonium chloride]
Pazeo: 0.7% (2.5 mL) [contains benzalkonium chloride]
Generic: 0.1% (1 mL, 5 mL, 10 mL, 15 mL); 0.2% (2.5 mL)
Ophthalmic: For topical ophthalmic use only. Wash hands prior to use. Do not touch tip of container to eye. After instilling drops, wait ≥10 minutes before inserting contact lenses. Do not insert contacts if eyes are red. If using other eye drops, wait at least 5 minutes before administering other eye drops.
Ophthalmic: For topical ophthalmic use only; not for injection or oral use. Wash hands prior to use. Do not touch tip of container to eye, eyelid, or other surfaces. After instilling drops, wait ≥10 minutes before inserting contact lenses (contains benzalkonium chloride). Do not insert contacts if eyes are red. If using other eye drops/ointments, wait ≥5 minutes before or after administering other eye drops.
Allergic conjunctivitis: Treatment of ocular itching associated with allergic conjunctivitis.
OTC labeling (Pataday): Temporary relief of itching and redness of the eye(s) caused by grass, ragweed, pollen, and animal dander and hair.
Patanol may be confused with Platinol
Patanol [US, Canada, and multiple international markets] may be confused with Bétanol brand name for metipranolol [Monaco]
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Central nervous system: Headache (≤5%)
Gastrointestinal: Dysgeusia (2% to 5%), nausea (≤5%)
Infection: Cold symptoms (≤10%)
Neuromuscular & skeletal: Back pain (≤5%), weakness (≤5%)
Ocular: Abnormal sensation in eyes (2% to 5%), blurred vision (2% to 5%), dry eye syndrome (2% to 5%), superficial punctate keratitis (2% to 5%), burning sensation of eyes (≤5%), conjunctivitis (≤5%), eyelid edema (≤5%), eye pain (≤5%), eye pruritus (≤5%), foreign body sensation (≤5%), keratitis (≤5%), stinging of eyes (≤5%), hyperemia
Respiratory: Pharyngitis (≤10%), cough (≤5%), rhinitis (≤5%), sinusitis (≤5%)
Miscellaneous: Flu-like symptoms (≤5%), hypersensitivity (≤5%), infection (≤5%)
Hypersensitivity to olopatadine hydrochloride or any component of the formulation.
OTC labeling (Pataday): When used for self-medication, do not use if hypersensitive to olopatadine hydrochloride or any component of the formulation, or to treat contact lens-related irritation.
Other warnings/precautions:
• Contact lens: Not for use to treat contact lens-related irritation. Solution contains benzalkonium chloride; remove lens prior to administration and wait ≥10 minutes before reinserting. Do not use contact lenses if eyes are red.
• Self-medication (OTC use): Discontinue use and contact health care provider if eye pain or changes in vision occur, redness or irritation of the eye continues, or condition worsens or persists for >3 days. Do not use if solution changes color or becomes cloudy.
None known.
There are no known significant interactions.
Olopatadine has minimal systemic absorption following ophthalmic administration. Systemic absorption would be required in order for olopatadine to cross the placenta and reach the fetus.
It is not known if olopatadine (ophthalmic) is excreted in breast milk. The manufacturer recommends that caution be exercised when administering olopatadine (ophthalmic) to nursing women.
Selective histamine H1-antagonist; inhibits release of histamine from mast cells. Inhibits histamine induced effects on conjunctival epithelial cells.
Absorption: Low systemic absorption (Patanol prescribing information 2018).
Half-life elimination: ~3 hours (Meier 2017; Patanol prescribing Information 2018).
Excretion: Urine (60% to 70%, mostly as unchanged drug) (Patanol prescribing Information 2018).
Solution (Olopatadine HCl Ophthalmic)
0.1% (per mL): $1.82 - $51.30
0.2% (per mL): $4.22 - $71.76
Solution (Pataday Ophthalmic)
0.1% (per mL): $2.98
0.2% (per mL): $5.71
0.7% (per mL): $5.76
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