Summary of the major lipoprotein particles that participate in cholesterol efflux from cholesterol-loaded cells
Cholesterol-deficient and phospholipid-depleted apoA-I complexes (preβ migrating HDL/HDL-VS) and lipid-poor E-HDL secreted from the macrophage interact with the ABCA1 transporter; HDL-M (αHDL) and spherical E-HDL interact with the ATP-binding cassette transporter G1 (ABCG1) transporter. Cholesterol is also removed by passive diffusion and by SR-B1 utilizing either HDL-M or spherical E-HDL.
From: Rosenson RS, Brewer HB Jr, Davidson WS, et al. Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation 2012; 125:1905. DOI:
10.1161/CIRCULATIONAHA.111.066589. Reproduced with permission from Lippincott Williams & Wilkins. Copyright © 2012 American Heart Association. Unauthorized reproduction of this material is prohibited.
