| Medication classes and specific medications | Combined hormonal contraceptive | Progesterone-only pill | DMPA |
| Immunosuppressive |
| Mycophenolate | - Not recommended
- May decrease efficacy of combined hormonal contraceptive
| | |
| Cyclosporine | - Use with careful follow-up
- May increase cyclosporine level
| | |
| Glucocorticoid | - Use with careful follow-up
- May increase glucocorticoid level
| | |
| Anticoagulant |
| Warfarin | - Avoid or use with careful follow-up
- Reduces effect of warfarin
| - Use with careful follow-up
- Unknown
| - Use with careful follow-up
- Unknown
|
| Antiseizure medications |
| Barbiturates | - Not recommended
- Decreases efficacy of combined hormonal contraceptive
| | |
| Carbamazepine | - Not recommended
- Decreases efficacy of combined hormonal contraceptive
| | |
| Oxcarbazepine | - Not recommended
- Decreases efficacy of combined hormonal contraceptive
| | |
| Topiramate | - Not recommended
- Decreases efficacy of combined hormonal contraception
| | |
| Phenytoin | - Not recommended
- Increases phenytoin concentration and decreases efficacy of combined hormonal contraceptive
| | |
| Lamotrigine | - Not recommended
- Decreases lamotrigine concentration
| | |
| Other medications |
| Modafinil | - Not recommended
- Decreases efficacy of combined hormonal contraceptive
| | |
| Potassium-sparing diuretics | - Use with careful follow-up
- Hyperkalemia risk with drospirenone-containing combined hormonal contraceptive
| | |
