Dietary supplement: Oral: 100 mg once or twice daily.
Migraine, prevention (alternative agent) (off-label use):
Note: An adequate trial for assessment of effect is considered to be at least 2 to 3 months at a therapeutic dose (EHF [Steiner 2019]).
Oral: 400 mg once daily (Rahimdel 2015; Schoenen 1998).
(For additional information see "Vitamin B2 (riboflavin): Pediatric drug information")
Dietary supplement: Infants, Children, and Adolescents: A multivitamin preparation is most commonly used for the provision of riboflavin supplementation in pediatric patients; the use of a single-ingredient riboflavin product as a daily supplement for the prevention of deficiency in pediatric patients is very rare. If single-ingredient riboflavin supplement is necessary, consult product labeling for appropriateness of product in infants and young children in particular.
Migraine headache, prevention: Limited data available, efficacy results variable: Children ≥ 8 years and Adolescents: Oral: 200 to 400 mg once daily; dosing based on a retrospective study of 41 patients (ages 8 to 18 years) who received 200 mg/day (n=21) or 400 mg/day (n=20) as prophylaxis for migraine and migraine-type headaches; results showed significant reduction in primary endpoint of frequency of headache attack; 68.4% of patients had a ≥50% decrease in headache frequency during treatment (Condò 2009). However, in a prospective, placebo-controlled study of 48 patients (ages 5 to 15 years), patients received 200 mg/day (n=27) or placebo (n=21) and in the treatment group (riboflavin) no benefit compared to placebo for migraine frequency or intensity was observed; a high placebo responder rate was also reported (MacLennan 2008).
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule, Oral:
B-2-400: 400 mg
Generic: 50 mg [DSC]
Tablet, Oral:
Generic: 25 mg, 50 mg, 100 mg
Yes
Oral: Administer with food.
Oral: Administer with food
Dietary supplement
Migraine, prevention
Riboflavin may be confused with ribavirin
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Frequency not defined: Genitourinary: Urine discoloration (yellow-orange)
Other warnings/precautions:
• Vitamin deficiency: Single vitamin deficiency is rare; evaluate for other deficiencies.
None known.
There are no known significant interactions.
Water-soluble vitamins cross the placenta. Riboflavin requirements may be increased in patients who are pregnant (IOM 1998).
Riboflavin is found in breast milk. Concentrations may be influenced by supplements or maternal deficiency. Riboflavin requirements may be increased in patients who are breastfeeding (IOM 1998).
Dietary sources of riboflavin include liver, kidney, dairy products, green vegetables, eggs, whole grain cereals, yeast, and mushroom.
Dietary reference intake (IOM 1998):
1 to 6 months: Adequate intake: 0.3 mg/day
7 to 12 months: Adequate intake: 0.4 mg/day
1 to 3 years: RDA: 0.5 mg
4 to 8 years: RDA: 0.6 mg
9 to 13 years: RDA: 0.9 mg
14 to 18 years: RDA: Females: 1 mg; Males: 1.3 mg
≥19 years: RDA: Females: 1.1 mg; Males: 1.3 mg
Pregnancy: RDA: 1.4 mg
Lactation: RDA: 1.6 mg
Component of flavoprotein enzymes that work together, which are necessary for normal tissue respiration; also needed for activation of pyridoxine and conversion of tryptophan to niacin
Absorption: Readily via GI tract; increased with food
Metabolism: Hepatic
Half-life, biologic: 66 to 84 minutes
Excretion: 9% eliminated unchanged in urine
Capsules (B-2-400 Oral)
400 mg (per each): $0.16
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