Warts: Topical: Applied by physician only.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
Refer to adult dosing.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, External:
Podocon-25: 25% (15 mL)
No
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Solution, External:
Podofilm: 25% ([DSC])
Topical: For external use only; avoid contact with eyes. To be applied by medical professional only; cleanse and dry affected area prior to application. Shake well prior to use. Use applicator provided with product to apply sparingly to lesions; avoid contact with healthy tissue; allow to dry thoroughly. When applying for the first time, leave on for only 30 to 40 minutes to determine patient sensitivity. After first, use may leave on 1 to 4 hours depending on severity of lesion; systemic absorption may occur with prolonged contact. Do not treat large areas or many warts at one time. Do not use if wart or surrounding tissue is inflamed or irritated. Do not use on bleeding warts, moles, birthmarks, or unusual warts with hair growing from them. Remove drug with alcohol or soap and water once treatment time has elapsed.
Topical: For external use only; avoid contact with eyes. To be applied by medical professional only; cleanse and dry affected area prior to application. Shake well prior to use. Use applicator provided with product to apply sparingly to lesions; avoid contact with healthy tissue; allow to dry thoroughly. When applying for the first time leave on for only 30 to 40 minutes to determine patient sensitivity. After first use may leave on 1 to 4 hours depending on severity of lesion; systemic absorption may occur with prolonged contact. Do not treat large areas or many warts at one time. Remove drug thoroughly with alcohol or soap and water once treatment time has elapsed. Do not use if wart or surrounding tissue is inflamed or irritated. Do not use on bleeding warts, moles, birthmarks, or unusual warts with hair growing from them.
Warts: Topical treatment of soft external genital (venereal) warts (condylomata acuminata); compound benzoin tincture generally is used as the medium for topical application.
Note: CDC sexually transmitted infections guidelines no longer recommend podophyllum resin as an option for the treatment of external genital warts due to reports of systemic toxicity when applied incorrectly, and because of the availability of safer alternative agents. Use may be considered for provider-administered treatment under select conditions (CDC [Workowski 2021]).
The Institute for Safe Medication Practices (ISMP) includes this medication among its list of drugs that have a heightened risk of causing significant patient harm when used in error.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Frequency not defined.
Central nervous system: Coma, paresthesia, polyneuropathy
Gastrointestinal: Paralytic ileus
Hematologic & oncologic: Leukopenia, thrombocytopenia
Miscellaneous: Fever
Not to be used on bleeding warts, birthmarks, moles, or warts with hair growth; not to be used by patients with diabetes or poor circulation; concurrent use of steroids; pregnancy; breastfeeding.
Other warnings/precautions:
• Appropriate use: Use of large amounts of drug should be avoided. For external use only; avoid contact with the eyes as it can cause severe corneal damage; do not apply to moles, birthmarks, or unusual warts; do not use if wart or surrounding tissue is inflamed/irritated or contains open lesions. To be applied by a health care professional only.
None known.
There are no known significant interactions.
Fetal abnormalities, fetal death, and stillbirth have been reported following use of podophyllum resin in patients who are pregnant. Use is contraindicated during pregnancy.
It is not known of podophyllum resin is present breast milk.
Use in breastfeeding patients is contraindicated by the manufacturer.
Directly affects epithelial cell metabolism by arresting mitosis through binding to a protein subunit of spindle microtubules (tubulin)
Solution (Podocon-25 External)
25% (per mL): $8.17
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