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Lip gland histopathology in Sjögren's syndrome

Lip gland histopathology in Sjögren's syndrome
(A) High-power view showing a portion of a normal salivary gland lobule with mucous acini and a striated duct (arrow).
(B) Low-power view showing a salivary gland lobule with two focal areas of lymphocytic infiltration (arrows). This histopathologic pattern is known as "focal lymphocytic sialadenitis" and is characteristic of Sjögren's syndrome.
(C) High-power view of a lymphocytic infiltrate with a germinal center-like structure. These are present in approximately 20% of minor salivary gland biopsies.
Courtesy of Alan N Baer, MD.
Graphic 97541 Version 2.0