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Monitoring of patients with suspected or established cystic fibrosis-related diabetes

Monitoring of patients with suspected or established cystic fibrosis-related diabetes
Blood glucose
  • Post prandial – Target <140 mg/dL (7.8 mmol/L) at 1 to 2 hours.
  • Fasting blood glucose – Target 70 to 90 mg/dL (3.9 to 5 mmol/L), when on basal insulin.
A1C Check every 3 months. Aim for low-normal values (eg, <5.5%). A1C values should decrease after initiating insulin.
Continuous glucose monitoring 
  • For screening – May be helpful if a patient has dysglycemia and indications for insulin treatment are unclear.
  • For treatment – Suggested if a patient is on insulin but has poor growth. 
Complications screening[1]

Blood pressure measurement at all routine visits.  

Annual screening for microvascular complications, beginning 5 years after the diagnosis of CFRD:

  • Dilated eye examination for retinopathy
  • Urine albumin:creatinine ratio (spot specimen)
  • Foot examination with testing for vibration (tuning fork) and pressure (10 g monofilament)
  • Lipid profile for selected patients with risk factors for hyperlipidemia (post transplantation, obesity, or family history of early coronary artery disease)  
Pulmonary function testing Perform every 3 months to assess lung function. Optimal therapy for CFRD tends to improve pulmonary function.
A1C: hemoglobin A1c (glycated hemoglobin); CFRD: cystic fibrosis-related diabetes.
References:
  1. ​Moran A, Brunzell C, Cohen RC, et al. Clinical care guidelines for cystic fibrosis-related diabetes: a position statement of the American Diabetes Association and a clinical practice guideline of the Cystic Fibrosis Foundation, endorsed by the Pediatric Endocrine Society. Diabetes Care 2010; 33:2697.
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