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Spectrum of widely investigated biomarkers for Alzheimer disease

Spectrum of widely investigated biomarkers for Alzheimer disease
  Pathophysiologic marker Topographic marker Marker of neuronal injury/degeneration
Cerebrospinal fluid
Aβ42 or Aβ42:Aβ40 ratio Yes No No
Total tau, phospho-tau Yes No Yes
PET
Amyloid tracer uptake Yes No No
Fluorodeoxyglucose No Yes Yes
Structural MRI
Medial temporal lobe atrophy No Yes Yes
Aβ: beta-amyloid; MRI: magnetic resonance imaging.
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