Pathophysiologic marker | Topographic marker | Marker of neuronal injury/degeneration | |
Cerebrospinal fluid | |||
Aβ42 or Aβ42:Aβ40 ratio | Yes | No | No |
Total tau, phospho-tau | Yes | No | Yes |
PET | |||
Amyloid tracer uptake | Yes | No | No |
Fluorodeoxyglucose | No | Yes | Yes |
Structural MRI | |||
Medial temporal lobe atrophy | No | Yes | Yes |