Targets of %fT>MIC for sub-classes of beta-lactams and gram-negative organisms
Targets of %fT>MIC for sub-classes of beta-lactams and gram-negative organisms
Bacteria-killing mechanism
Penicillins (%)
Cephalosporins (%)
Carbapenems (%)
Bacteriostatic
30%
35-40%
20%
Bacteriocidal
50%
60-70%
40%
%fT>MIC: percentage of the dosing interval that the concentration of free drug remains about the minimum inhibitory concentration of the pathogen.
Data from: Lodise TP, Lomaestro BM, Drusano GL, Society of Infectious Diseases Pharmacists. Application of antimicrobial pharmacodynamic concepts into clinical practice: focus on beta-lactam antibiotics: insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy 2006; 26:1320 and Craig WA, Ebert S, and Wantabe Y. Differences in time above MIC required for efficacy of beta-lactams in animal infection models. Presented at the 33rd Interscience Conference on Animicrobial Agents and Chemotherapy, San Francisco CA, 1993, Abstract #86.