Hepatic disease | Nonhepatic disease |
ALT predominant (AST/ALT <1) | AST predominant (AST/ALT ≥1) | |
Drug-induced liver injury | Alcohol-associated hepatitis | Muscle injury (strenuous exercise, myopathy) |
Chronic viral hepatitis (HBV, HCV) | Cirrhosis due to viral hepatitis or NAFLD | Adrenal insufficiency |
Occupational, toxin-related hepatocellular damage | Wilson disease | Myocardial infarction, heart failure |
Autoimmune hepatitis | | Anorexia nervosa |
NAFLD | | Thyroid disease |
Genetic disorders - Wilson disease
- Hemochromatosis
- Alpha-1 antitrypsin deficiency
| | Celiac disease |
Congestive hepatopathy | | Macro-AST |
Malignant infiltration of the liver | | |