| NOTE: These formulations require swallowing; other formulations that are absorbed transmucosally and do not require swallowing (eg, sublingual, buccal) are provided in a separate table | |
| Drug | Available strengths* |
| Analgesic, antiinflammatory, antipyretic, antimigraine | |
| Acetaminophen (paracetamol) | 80, 160 mg |
| Ibuprofen (ODT not available in United States) | 200 mg |
| Meloxicam | 7.5, 15 mg |
| Nimesulide (not available in United States) | 100 mg |
| Piroxicam (ODT not available in United States) | 20 mg |
| Rimegepant | 75 mg |
| Rizatriptan | 5, 10 mg |
| Tramadol (ODT not available in United States) | 50 mg |
| Zolmitriptan | 2.5, 5 mg |
| Antidepressant | |
| Escitalopram (ODT not available in United States) | 10, 20 mg |
| Mirtazapine | 15, 30, 45 mg |
| Antihistamine | |
| Cetirizine | 10 mg |
| Desloratadine | 2.5, 5 mg |
| Diphenhydramine | 12.5 mg (dispersible film) |
| Fexofenadine | 30 mg |
| Loratadine | 5, 10 mg |
| Antipsychotic | |
| Aripiprazole | 10, 15 mg |
| Clozapine | 12.5, 25, 100, 150, 200 mg |
| Olanzapine | 5, 10, 15, 20 mg |
| Risperidone | 0.25, 0.5, 1, 2, 3, 4 mg |
| Cough and cold | |
| Benzocaine | 6% (dispersible film, local effect) |
| Dextromethorphan | 7.5 mg (dispersible film) |
| Gastrointestinal | |
| Famotidine (ODT not available in United States) | 20 mg |
| Glycopyrrolate | 1.7 mg |
| Hyoscyamine | 0.125 mg |
| Lansoprazole (delayed release) | 15, 30 mg |
| Loperamide (ODT not available in United States) | 2 mg |
| Metoclopramide | 5, 10 mg |
| Ondansetron | 4, 8 mg (ODT; dispersible film available in some countries other than United States) |
| Simethicone | 40, 62.5 mg (dispersible film) |
| Glucocorticoid | |
| Prednisolone | 10, 15, 30 mg |
| Neurologic | |
| Alprazolam | 0.25, 0.5, 1, 2 mg |
| Amphetamine | 5, 10, 15, 20 mg |
| Amphetamine (extended release) | 3.1, 6.3, 9.4, 12.5, 15.7, 18.8 mg |
| Baclofen (granules in packets) | 5, 10, 20 mg |
| Clobazam | 5, 10, 20 mg |
| Carbidopa-levodopa | 10-100, 25-100, 25-250 mg |
| Clonazepam | 0.125, 0.25, 0.5, 1, 2 mg |
| Donepezil | 5, 10 mg |
| Fingolimod | 0.25, 0.5 mg |
| Lamotrigine | 25, 50, 100, 200 mg |
| Methylphenidate (extended release) | 8.6, 17.3, 25.9 mg |
| Riluzole | 50 mg (dispersible film) |
| Selegiline | 1.25 mg |
| Zolpidem | 5 mg/actuation (oral spray) |
| Other | |
| Vardenafil | 10 mg |
Orally disintegrating (also known as orodispersible) tablets and films are designed to dissolve rapidly in saliva and provide a useful alternative to pills for patients with non-severe swallowing difficulties. The tablet or film is dissolved on top of the tongue and can be taken without water. This method of administration requires swallowing of dissolved pharmaceutical for adequate absorption and is not appropriate for use in patients with severe dysphagia.
This is not an exhaustive list of orally disintegrating medications. For additional information including indications, dosage, and precautions, refer to the relevant clinical topics and Lexicomp drug monographs included within UpToDate.ODT: orally disintegrating tablet.
* Strengths listed are for ODTs unless otherwise noted.