Agent | Initial daily dose | Suggested dose titration based upon response | Maintenance daily dose range | Selected characteristics* |
Selective serotonin reuptake inhibitors (SSRIs)* | ||||
Fluoxetine¶ | Children: 5 to 10 mg Adolescents: 10 to 20 mg | Increase daily dose by 5 to 10 mg (child) or 10 to 20 mg (adolescent) after 14 days or more | Pre-adolescent: 20 to 30 mg Adolescent: 20 to 60 mg |
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Fluvoxamine¶ | 25 mg at bedtime | Increase daily dose by 25 mg (child) or 25 to 50 mg (adolescent) after 7 days or more | Pre-adolescent: 50 to 200 mg Adolescent: 50 to 300 mg |
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Sertraline¶ | Children: 25 mg Adolescents: 50 mg | Increase daily dose by 25 (child) or 50 mg (adolescent) after 7 days or more | 25 to 200 mg |
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Selective serotonin reuptake inhibitors (SSRI) - potential alternate* | ||||
Paroxetine | Children age ≥7 years: 5 mg Adolescents: 10 mg | Increase daily dose by 10 mg after 7 to 14 days or more | 10 to 60 mg |
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Tricyclic antidepressant (TCA) | ||||
Clomipramine¶ | Children ≥10 years old and adolescents: 25 mg | Increase daily dose by 25 mg every 7 to 14 days or more | 25 to 200 mg Maximum: smaller of 200 mg or 3 mg/kg per dayΔ |
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Second generation antipsychotics (SGAs) for SSRI augmentation | ||||
Risperidone | 0.25 mg | Increase daily dose by 0.25 mg after 7 to 14 days or more | Maximum: 1.5 to 2 mg |
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