| Absolute contraindications |
| Prior intracranial hemorrhage |
| Known structural cerebral vascular lesion |
| Known malignant intracranial neoplasm |
| Ischemic stroke within three months (excluding stroke within three hours*) |
| Suspected aortic dissection |
| Active bleeding or bleeding diathesis (excluding menses) |
| Significant closed-head trauma or facial trauma within three months |
| Relative contraindications |
| History of chronic, severe, poorly controlled hypertension |
| Severe uncontrolled hypertension on presentation (SBP >180 mmHg or DBP >110 mmHg) |
| History of ischemic stroke more than three months prior |
| Traumatic or prolonged (>10 minute) CPR or major surgery less than three weeks |
| Recent (within two to four weeks) internal bleeding |
| Noncompressible vascular punctures |
| Recent invasive procedure |
| For streptokinase/anistreplase - Prior exposure (more than five days ago) or prior allergic reaction to these agents |
| Pregnancy |
| Active peptic ulcer |
| Pericarditis or pericardial fluid |
| Current use of anticoagulant (eg, warfarin sodium) that has produced an elevated international normalized ratio (INR) >1.7 or prothrombin time (PT) >15 seconds |
| Age >75 years |
| Diabetic retinopathy |
