| Treatable contributing factor | Examples of possible diagnostic evaluation* |
| Cardiac dysfunction (eg, arrhythmia, hypertension, coronary artery disease, heart failure) | Consider echocardiogram, exercise test for cardiopulmonary reserve |
| Endocrine dysfunction (eg, diabetes, hypothyroidism, hypogonadism, adrenal insufficiency) | Consider measuring HgbA1C, TSH, glucose, and testosterone, conduct dexamethasone suppression test |
| Pulmonary dysfunction | Consider chest x-ray, six-minute walk test, pulmonary function tests, oxygen saturation |
| Renal dysfunction | Consider kidney and electrolyte chemistries |
| Anemia | Consider CBC |
| Arthritis | Consider erythrocyte sedimentation rate (ESR), serologies |
| Neuromuscular complications (neuromuscular degerative disease, neuropathy) | Consider grip strength test, neuropathy sensory testing, electromyography |
| Sleep disturbances (eg, insomnia, sleep apnea, vasomotor symptoms, restless leg syndrome) | Consider assessing sleep with standardized questionnaire, possible sleep study |
| Pain | Evaluate with standardized assessment tool |
| Emotional distress (eg, anxiety, depression) | Evaluate with standardized assessment tool or diagnostic interview |
