| Antimicrobial | Regimen | Maximum single dose |
| Amoxicillin*¶ | 13.3 mg/kg 3 times per day | 500 mg |
| Amoxicillin-clavulanate (immediate release formulations)* | 22.5 mg amoxicillin/kg twice per day | 875 mg amoxicillin |
| Cefdinir | 14 mg/kg once per day | 600 mg |
| Cefixime | 4 mg/kg twice per day | 200 mg |
| Cefpodoxime | 5 mg/kg twice per day | 200 mg |
| Cefprozil | 15 mg/kg twice per day | 500 mg |
| Ceftibuten | 9 mg/kg once per day | 400 mg |
| Cefuroxime | 15 mg/kg twice per day | 500 mg |
| NitrofurantoinΔ | 1.25 to 1.75 mg/kg 4 times per day | 100 mg |
| Trimethoprim-sulfamethoxazole (TMP-SMX)*Δ | 4 to 6 mg trimethoprim/kg twice per day | 160 mg TMP |
* Escherichia coli strains may be resistant to amoxicillin, amoxicillin-clavulanate, and trimethoprim-sulfamethoxazole; therapy should be determined based on local susceptibility patterns.
¶ May be indicated if Enterococcus is suspected based on Gram stain, culture, or clinical features (eg, underlying genitourinary abnormality, recurrent urinary tract infection).
Δ May be indicated if Staphylococcus saprophyticus is suspected based on Gram stain, culture, or clinical features (sexually active female adolescent).