| Reaction | Clinical findings | Laboratory findings | Implicated products |
| Acute hemolytic transfusion reaction | Fever, chills, hypotension, back pain, DIC | Hemoglobinemia, hemoglobinuria, positive direct antiglobulin (Coombs) test (may be negative if all cells have hemolyzed), findings of DIC (prolonged PT, prolonged aPTT, low fibrinogen, thrombocytopenia) | RBCs, plasma (much less common), rarely platelets Incompatible blood product (typically ABO incompatible due to clerical error) |
| Anaphylactic transfusion reaction | Hypotension, angioedema, wheezing, respiratory distress | Hypoxemia, IgA deficiency, anti-IgA | RBCs, platelets, plasma products |
| Transfusion-related acute lung injury (TRALI) | Respiratory distress, hypotension | Abnormal chest radiography, hypoxemia, transient leukopenia, anti-neutrophil or anti-HLA antibodies (if tested) | RBCs, platelets, plasma products |
| Transfusion-associated circulatory overload (TACO) | Respiratory distress, rales | Abnormal chest radiography, hypoxemia, increased BNP or NT-proBNP | RBCs, platelets, plasma products, and other fluids |
| Sepsis/bacterial infection | Fever, chills, hypotension, DIC | Bacteremia, leukocytosis, findings of DIC | Platelets most commonly implicated, but can be any product Product may show bacterial contamination |
| Febrile non-hemolytic transfusion reaction | Fever | None | All blood products, but plasma is much rarer |
| Allergic transfusion reaction | Hives, urticaria | None unless specific investigation is made | All blood products |
