| Administration route | Preparation | Initial dose | Usual dose range |
| IM | Solution (testosterone enanthate, testosterone cypionate) | 75 to 100 mg once weekly, or 150 to 200 mg every 2 weeks* | 50 to 100 mg once weekly, or 100 to 200 mg every 2 weeks* |
| Solution (testosterone undecanoate) | 750 mg; repeat 750 mg dose after 4 weeks, and then every 10 weeks thereafter | ||
| Intranasal | Gel (Natesto) | 11 mg (2 pump actuations; 1 actuation per nostril) 3 times daily (6 to 8 hours apart) | |
| Oral | Capsule (Jatenzo) | 237 mg twice daily | 158 to 396 mg twice daily |
| Capsule (Tlando) | 225 mg twice daily | Dose is not adjusted; may continue use at fixed dose if serum testosterone concentrations remain within normal range | |
| Capsule (testosterone undecanoate)¶ | 120 to 160 mg/day in 2 divided doses for 2 to 3 weeks | 40 to 120 mg/day | |
| SubQ (injection) | Solution (Xyosted) | 75 mg once weekly | 50 to 100 mg once weekly |
| SubQ (implantation) | Pellet (Testopel) | 150 to 450 mg every 3 to 6 months | |
| Topical | 1% Gel (eg, AndroGel 1%, Testim, Vogelxo) | 50 mg applied once daily in the morning to the shoulders and/or upper armsΔ◊ | 50 to 100 mg/day (maximum: 100 mg/day)◊§ |
| 1.62% Gel (eg, AndroGel 1.62%) | 40.5 mg applied once daily in the morning to the shoulders and upper arms¥ | 20.25 to 81 mg/day (maximum: 81 mg/day)¥ | |
| 2% Gel (eg, Fortesta) | 40 mg (4 pump actuations) applied once daily in the morning to the thighs | 10 to 70 mg/day (1 to 7 pump actuations; maximum: 70 mg/day) | |
| Transdermal solution | 60 mg (2 pump actuations) applied once daily in the morning to the axillae | 30 to 120 mg/day (1 to 4 pump actuations) | |
| Transdermal system (Androderm) | 4 mg/day (as one 4 mg/day patch; do not use two 2 mg/day patches) | 2 to 6 mg/day‡ | |
IM: intramuscular; SubQ; subcutaneous.
* Dosing for this formulation is from the following sources: AUA (Mulhall 2018)[1], ES (Bhasin 2018)[2].
¶ Canadian product.
Δ AndroGel 1% may also be applied to the abdomen.
◊ For the testosterone 1% gel and Vogelxo pump formulations, 1 pump actuation = 12.5 mg.
§ Maximum dose according to manufacturers of Testim and Vogelxo.
¥ For the AndroGel 1.62% pump formulation, 1 pump actuation = 20.25 mg.
‡ Administer the 6 mg/day dose as one 2 mg/day patch and one 4 mg/day patch.Reproduced from: Lexicomp Online (Lexi-Interact). Copyright © 1978-2023 Lexicomp, Inc. All Rights Reserved.
