| Symptoms elicited in history |
| Constitutional - weight loss >10 pounds |
| Musculoskeletal - focal skeletal pain |
| Neurologic - headaches, syncope, seizures, extremity weakness, recent change in mental status |
| Signs found on physical exam |
| Lymphadenopathy (>1 cm) |
| Hoarseness, superior vena cava syndrome |
| Bone tenderness |
| Hepatomegaly (>13 cm span) |
| Focal neurologic signs, papilledema |
| Soft tissue mass |
| Routine laboratory tests |
| Hematocrit, <40% in males |
| Hematocrit, <35% in females |
| Elevated alkaline phosphatase, GGT, SGOT |
