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Clinical and histologic features of toxic epidermal necrolysis

Clinical and histologic features of toxic epidermal necrolysis
(A) Diffuse, coalescing, erythematous macules and patches with dusky centers and multiple bullae in a patient recently started on several new medications.
(B) There is a cell-poor subepidermal blister and epidermal necrosis. The dermal inflammatory infiltrate is sparse.
Reproduced with permission from: Wu H, Branding-Bennett HA, Harrist TJ. Noninfectious vesiculobullous and vesiculopustular diseases. In: Lever's Histopathology of the Skin, 10th ed, Elder DE, Elenitsas R, Johnson B Jr, et al (Eds), Lippincott Williams & Wilkins, Philadelphia, 2008. Copyright © 2008 Lippincott Williams & Wilkins. www.lww.com.
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