Note: Eurax cream and lotion have been discontinued in the US for >1 year.
Pruritus: Topical: Massage into affected areas until medication is completely absorbed; repeat as necessary
Scabies: Topical: Apply a thin layer and massage drug onto skin of the entire body from the neck to the toes (with special attention to skin folds, creases, and interdigital spaces). Repeat application in 24 hours. May re-treat if new lesions appear or itching persists more than 2 to 4 weeks after initial treatment (CDC 2018).
There are no dosage adjustments provided in manufacturer's labeling.
There are no dosage adjustments provided in manufacturer's labeling.
(For additional information see "Crotamiton: Pediatric drug information")
Note: Eurax cream and lotion have been discontinued in the US for >1 year.
Scabies: Limited data available: Infants, Children, and Adolescents: Topical: Apply a thin layer onto skin of entire body from neck to toes; apply once daily for 3 days followed by a cleansing bath 48 hours after the last application; treatment may be repeated after 7 days if mites appear; not typically first-line therapy as other agents have shown greater efficacy (Hay 2012; Kliegman 2016; Red Book [AAP 2015] ); longer duration of treatment (5 days) has also been reported and was well tolerated (Cubela 1978; 2014; Konstantinov 1979). Goldust
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
Refer to adult dosing.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Cream, External:
Eurax: 10% (60 g [DSC])
Lotion, External:
Crotan: 10% (60 g, 237 g, 454 g) [contains benzyl alcohol, cetyl alcohol, propylene glycol]
Eurax: 10% (60 g [DSC], 454 g [DSC])
No
Eurax cream and lotion have been discontinued in the US for >1 year.
Topical: For external use only; avoid eyes and mucous membranes. Shake lotion well before using. Take a bath or shower prior to application. Apply from neck down to toes. Trim fingernails and apply under nails (can use toothbrush, which should be disposed of after use). Take a cleansing bath 48 hours after the final application. Contaminated clothing and bed linens should be washed on hot cycle or dry-cleaned and all clothing and bedding should be changed the day after application.
Topical: For external use only; avoid eyes and mucous membranes. Shake lotion well before using. Wash thoroughly and scrub away loose scales, then towel dry; apply a thin layer and gently massage drug onto skin of the entire body from the neck to the toes (with special attention to skin folds, creases, and interdigital spaces); also apply cream or lotion under fingernails after trimming nails short; since scabies can affect the head, scalp, and neck in infants and young children, apply to scalp, neck, and body of this age group (Red Book [AAP 2015]); do not apply to the face, eyes, mouth, mucous membranes, or urethral meatus. Take a cleansing bath 48 hours after the final application. Contaminated clothing and bed linens should be washed on hot cycle or dry-cleaned and all clothing and bedding should be changed the day after application.
Treatment of scabies (Sarcoptes scabiei) and symptomatic treatment of pruritus
Eurax may be confused with Efudex, Eulexin, Evoxac, Serax, Urex
Eurax [US, Canada, and multiple international markets] may be confused with Urex brand name for furosemide [Australia, China, Turkey] and methenamine [US, Canada]
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.
Central nervous system: Localized warm feeling
Dermatologic: Contact dermatitis, pruritus, skin rash
Hypersensitivity: Local hypersensitivity reaction
Local: Local irritation
Hypersensitivity to crotamiton or any component of the formulation; patients who manifest a primary irritation response to topical medications
Other warnings/precautions:
• Appropriate use: For external use only; avoid contact with face, eyes, mucous membranes, and urethral meatus. Do not apply to acutely inflamed, raw, or weeping skin. Discontinue use if severe irritation or sensitization occurs.
Some dosage forms may contain propylene glycol; in neonates large amounts of propylene glycol delivered orally, intravenously (eg, >3,000 mg/day), or topically have been associated with potentially fatal toxicities which can include metabolic acidosis, seizures, renal failure, and CNS depression; toxicities have also been reported in children and adults including hyperosmolality, lactic acidosis, seizures, and respiratory depression; use caution (AAP 1997; Shehab 2009).
None known.
There are no known significant interactions.
Animal reproduction studies have not been conducted; use during pregnancy only if clearly needed.
It is not known if crotamiton is excreted in breast milk.
Crotamiton has scabicidal activity against Sarcoptes scabiei; mechanism of action unknown. Antipruritic effects mediated by inhibition of histamine, serotonin, and PAR-2 (Sekine 2012).
Absorption: Amount of systemic absorption following topical use has not been determined
Lotion (Crotan External)
10% (per gram): $8.10
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