I. Clinical diagnosis of logopenic variant PPA |
Both of the following core features must be present: |
- Impaired single-word retrieval in spontaneous speech and naming
- Impaired repetition of sentences and phrases
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At least 3 of the following other features must be present: |
- Speech (phonologic) errors in spontaneous speech and naming
- Spared single-word comprehension and object knowledge
- Spared motor speech
- Absence of frank agrammatism
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II. Imaging-supported diagnosis of logopenic variant PPA |
Both criteria must be present: |
- Clinical diagnosis of logopenic variant PPA
- Imaging must show at least one of the following results:
a. Predominant left posterior perisylvian or parietal atrophy on MRI b. Predominant left posterior perisylvian or parietal hypoperfusion or hypometabolism on SPECT or PET |
III. Logopenic variant PPA with definite pathology |
Clinical diagnosis (criterion 1 below) and either criterion 2 or 3 must be present: |
- Clinical diagnosis of logopenic variant PPA
- Histopathologic evidence of a specific neurodegenerative pathology (eg, AD, FTLD-tau, FTLD-TDP, other)
- Presence of a known pathogenic mutation
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