| A. Evidence of significant cognitive decline from a previous level of performance in one or more cognitive domains*: |
| Learning and memory. |
| Language. |
| Executive function. |
| Complex attention. |
| Perceptual-motor. |
| Social cognition. |
| B. The cognitive deficits interfere with independence in everyday activities. At a minimum, assistance should be required with complex instrumental activities of daily living, such as paying bills or managing medications. |
| C. The cognitive deficits do not occur exclusively in the context of a delirium. |
| D. The cognitive deficits are not better explained by another mental disorder (eg, major depressive disorder, schizophrenia). |
| E. There is insidious onset and gradual progression of impairment in at least two cognitive domains. |
| F. Either of the following: |
| Evidence of a causative Alzheimer disease genetic mutation from family history or genetic testing. |
| All three of the following are present: |
| 1) Clear evidence of decline in memory and learning and at least one other cognitive domain. |
| 2) Steadily progressive, gradual decline in cognition, without extended plateaus. |
| 3) No evidence of mixed etiology (ie, absence of other neurodegenerative disorders or cerebrovascular disease, or another neurological, mental, or systemic disease or condition likely contributing to cognitive decline). |
