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Mast cell structure on electron microscopy

Mast cell structure on electron microscopy
Micrograph A shows a mast cell from human lung tissue in which there are granules containing scroll-like structures. It is unclear precisely what these structures are composed of, although the granules contain predominantly tryptase. A higher power image of these scroll-like structures (yellow arrows) is shown in micrograph C. The black arrows point to granules with an amorphous structure, which likely represent developing (as opposed to mature) granules.
Micrograph B shows a mast cell from the skin with granules that display a lattice-like grating pattern on electron microscopy. The granules in this type of mast cell contain carboxypeptidase A, chymase, and tryptase. A higher power image of these granules (yellow arrows) is shown in micrograph D.
Reprinted by permission from Macmillan Publishers Ltd: Journal of Investigative Dermatology. Weidner N, Austen KF. Ultrastructural and immunohistochemical characterization of normal mast cells at multiple body sites. J Invest Dermatol 1991; 96:26S. Copyright © 1991. www.nature.com/jid.
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