Cardiac output determination: IV: 5 mg injected rapidly via a cardiac catheter; maximum total dose: 2 mg/kg.
Note: An average of 5 dilution curves are needed in a diagnostic cardiac catheterization; doses are usually injected in 1 mL volume. Flush dye from catheter with NS to prevent hemolysis.
Hepatic function studies: IV: 0.5 mg/kg; patient should be in a fasting basal state
Ophthalmic angiography: IV: Up to 40 mg (depending on the imaging equipment and technique used); immediately follow with a 5 mL bolus of NS.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Cardiac output determination: IV: Note: An average of 5 dilution curves are needed in a diagnostic cardiac catheterization; doses are usually injected in 1 mL volume. Flush dye from catheter with NS to prevent hemolysis.
Infants: 1.25 mg injected rapidly via a cardiac catheter; maximum total dose: 2 mg/kg.
Children and Adolescents: 2.5 mg injected rapidly via a cardiac catheter; maximum total dose: 2 mg/kg.
Hepatic function studies: Infants, Children, and Adolescents: Refer to adult dosing.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution Reconstituted, Intravenous:
IC Green: 25 mg (1 ea)
Generic: 25 mg (1 ea)
Yes
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution Reconstituted, Injection:
Spy Agent Green: 25 mg (1 ea)
Spy Agent Green Lymphat Pinpoi: 25 mg (1 ea)
Spy Agent Green Pinpoint: 25 mg (1 ea)
Spy Agent Green Spy Elite: 25 mg (1 ea)
Spy Agent Green Spy Phi: 25 mg (1 ea)
Solution Reconstituted, Intravenous:
Generic: 25 mg (1 ea)
IV:
Cardiac output determination: In the performance of dye dilution curves, administer as a single bolus as rapidly as possible via a cardiac catheter into selected sites in the vascular system. Inject the dose of dye in 1 mL volume; an average of 5 dilution curves are recommended in the procedure. Attach a recording instrument (oximeter or densitometer) to a needle or catheter for sampling of the dye-blood mixture from a systemic arterial sampling site. Use sterile water for injection to rinse the syringe; use isotonic saline to flush the residual dye from the cardiac catheter into circulation to avoid hemolysis; saline should be used in all other parts of the catheterization procedure. See manufacturer’s labeling for specific information regarding calibration of dye curves.
Hepatic function studies: Inject into the lumen of an arm vein as rapidly as possible, without allowing the dye to escape outside the vein. If the photometric method is used, prior to injecting indocyanine green, withdraw 6 mL venous blood from the patients arm for serum blank and standard curve construction, and through the same needle, inject the correct amount of dye. Ear oximetry has also been used; see manufacturer’s labeling for additional information.
Ophthalmic angiography studies: Administer as a bolus injection into the antecubital vein; immediately follow with a 5 mL bolus of normal saline.
IV:
Cardiac output determination: In the performance of dye dilution curves, administer as a single bolus as rapidly as possible via a cardiac catheter into selected sites in the vascular system. Inject the dose of dye in 1 mL volume; an average of 5 dilution curves are recommended in the procedure. Attach a recording instrument (oximeter or densitometer) to a needle or catheter for sampling of the dye-blood mixture from a systemic arterial sampling site. Use SWFI to rinse the syringe; use NS to flush the residual dye from the cardiac catheter into circulation to avoid hemolysis; NS should be used in all other parts of the catheterization procedure. See manufacturer's labeling for specific information regarding calibration of dye curves.
Hepatic function studies: Inject into the lumen of an arm vein as rapidly as possible, without allowing the dye to escape outside the vein. If the photometric method is used, prior to injecting indocyanine green, withdraw 6 mL venous blood from the patient's arm for serum blank and standard curve construction, and through the same needle, inject the correct amount of dye. Ear oximetry has also been used; see manufacturer's labeling for additional information.
Cardiac/hepatic function diagnostics: For determining cardiac output, hepatic function, and liver blood flow.
Ophthalmic angiography: For ophthalmic angiography.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.
Central nervous system: Headache
Dermatologic: Pruritus, urticaria
Gastrointestinal: Feces discoloration (green)
Miscellaneous: Anaphylactoid reactions, diaphoresis
Hypersensitivity to iodides
Concerns related to adverse effects:
• Anaphylaxis: Anaphylaxis has been reported, including deaths during cardiac catheterization procedures
None known.
There are no known significant interactions.
Reproduction studies have not been done.
It is not known if indocyanine green is excreted in breast milk. The manufacturer recommends that caution be exercised when administering indocyanine green to nursing women.
Normal percentage disappearance rate is 18% to 24% per minute
Indocyanine dye is a tricarbocyanine dye that permits recording of the indicator-dilution curves for both diagnostic and research purposes independently of fluctuations in oxygen saturation.
Protein binding: 95% to albumin
Half-life elimination: 2.5 to 3 minutes
Excretion: Bile
Solution (reconstituted) (IC Green Intravenous)
25 mg (per each): $136.72
Solution (reconstituted) (Indocyanine Green Intravenous)
25 mg (per each): $98.96 - $121.04
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