Criteria | Points |
1) Family history |
- First-degree relative with known premature (men: <55 years; women: <60 years) coronary or vascular disease, or
- First-degree relative with known LDL-C above the 95th percentile
| 1 |
- First-degree relative with tendinous xanthomata and/or arcus cornealis, or
- Children <18 years of age with LDL-C above the 95th percentile
| 2 |
2) Clinical history |
- Patient with premature (men: <55 years; women: <60 years) coronary artery disease
| 2 |
- Patient with premature (men: <55 years; women: <60 years) cerebral or peripheral vascular disease
| 1 |
3) Physical examination |
| 6 |
- Arcus cornealis before age 45 years
| 4 |
4) LDL-C levels |
- LDL-C ≥8.5 mmol/L (325 mg/dL)
| 8 |
- LDL-C 6.5 to 8.4 mmol/L (251-325 mg/dL)
| 5 |
- LDL-C 5 to 6.4 mmol/L (191-250 mg/dL)
| 3 |
- LDL-C 4 to 4.9 mmol/L (155-190 mg/dL)
| 1 |
5) DNA analysis |
- Functional mutation in the LDLR, apoB, or PCSK9 gene
| 8 |
Choose only one score per group, the highest applicable diagnosis (diagnosis is based on the total number of points obtained) - A "definite" FH diagnosis requires >8 points
- A "probable" FH diagnosis requires 6 to 8 points
- A "possible" FH diagnosis requires 3 to 5 points
|