Disease-related indication |
Suitable donor available |
Karnofsky performance status ≥70 for a myeloablative HCT or ≥50 for a nonmyeloablative HCT |
Renal function: - While no specific cutoff is universally used, many centers limit allo-HCT to those with a serum creatinine <2 mg/dL (177 micromol/L) or CrCl >50
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Cardiac reserve: |
Pulmonary function: - A corrected DLCO >35 percent
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Liver function: - No frank cirrhosis of the liver
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Adequate psychosocial and financial support |
While no specific age cutoff is universally used, many centers limit myeloablative allo-HCT to patients <55 years and reduced intensity allo-HCT to patients <75 years |