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Uptodate Reference Title
Diagnostic accuracy of imaging modalities for preoperative parathyroid localization
Diagnostic accuracy of imaging modalities for preoperative parathyroid localization
Imaging modality
Sensitivity (percent)
Positive predictive value (percent)
Sestamibi
71-79
72-95
Sestamibi-SPECT
70-81
91-95
Ultrasound
64-91
83-96
4D-CT
83-95
88-99
MRI
40-85
N/A
MET-PET-CT scan
79-90
93-94
18F-fluorocholine PET
75-98
66-98
SPECT: sestamibi-single photon emission computed tomography; CT: computed tomography; MRI: magnetic resonance imaging; N/A: not applicable; MET-PET-CT scan: 11C-methionine positron emission tomography and computed tomography; PET: positron emission tomography.
Data from:
Cheung K, Wang TS, Farrokhyar F, et al. A meta-analysis of preoperative localization techniques for patients with primary hyperparathyroidism. Ann Surg Oncol 2012; 19:577.
Mihai R, Simon D, Hellman P. Imaging for primary hyperparathyroidism--an evidence-based analysis. Langenbecks Arch Surg 2009; 394:765.
Weber T, Maier-Funk C, Ohlhauser D, et al. Accurate Preoperative Localization of Parathyroid Adenomas With C-11 Methionine PET/CT. Ann Surg 2013; 257:1124.
Piccardo A, Bottoni G, Boccalatte LA. Head-to-head comparison among 18F-choline PET/CT, 4D contrast-enhanced CT, and 18F-choline PET/4D contrast-enhanced CT in the detection of hyperfunctioning parathyroid glands: A systematic review and meta-analysis. Endocrine 2021; 74:404.
