| Cytogenetic finding | Affected genes | Clinical features | Prognosis | Approximate incidence in de novo AML |
| t(8;21) | RUNX1/RUNX1T1 | Younger adults (average age 30 years) AML with maturation (FAB M2) Auer rods usually present | Favorable | 5 to 7% |
| t(15;17) | PML/RARA | Younger adults (average age 40 years) Atypical promyelocytes with bilobed nucleus and granules (APL, FAB M3) Disseminated intravascular coagulation common | Favorable; high cure rate with all-trans retinoic acid-based therapy | 5 to 8% |
| t(11;17) | ZBTB16/RARA | Similar to APL but with sparser granules and absence of the typical bilobed nucleus | Poor response to all-trans retinoic acid-based treatment | <1% |
| abn(16q22) | CBFB/MYH11 | Younger adults (average age 35 to 40 years) Acute myelomonocytic leukemia (FAB M4) with eosinophilia | Favorable; high reinduction rate post relapse | 5% |
| abn(11q23) | MLL and many partners | Older adults (average age >50 years) Acute monoblastic and monocytic leukemia (FAB M5) Hyperleukocytosis and extramedullary disease common | Poor, except t(9;11) | 3% |
| +8 | Older adults (average age >60 years) Varied morphology Often associated with other chromosomal additions and deletions | Poor | 3 to 10% | |
| del 5, del 7, 5q-, 7q-, or combinations | Older adults (average age >60 years) Varied morphology, common in acute erythroid leukemia (FAB M6) Common in patients with secondary AML and prior MDS | Poor | 15 to 20% | |
| Inv 3 | RPN1/MECOM | Morphologically abnormal megakaryocytes; increased platelet count Other abnormalities common (del 5,7) | Poor | <1% |
| abn(p17) | TP53 | Younger adults (average age <60 years) Varied morphology Other abnormalities common (del 5,7, complex karyotype) | Poor | 5% |
| +13 | Older adults (average age >60 years) Varied morphology, sometimes undifferentiated, high frequency of hybrid features | Poor | Approximately 1 to 2% | |
| t(6;9)(p2;q34) | DEK/NUP214 | AML with maturation (FAB M2)/Acute myelomonocytic leukemia (FAB M4) with prominent basophilia | Poor | <1 to 2% |
| t(9;22) | BCR/ABL1 | Older adults (average age >50 years) Usually AML with minimal differentiation (FAB M1), prominent splenomegaly, possible transformation of unrecognized CML | Poor | Approximately 1% |
| t(1;22) | RBM15/MKL1 | Infants (aged 0 to 3 years) Often acute megakaryoblastic leukemia (FAB M7), prominent organomegaly | Poor | <1% |
| t(8;16) | KAT6A/CREBBP | Acute myelomonocytic leukemia (FAB M4) and acute monoblastic and monocytic leukemia (FAB M5), erythrophagocytosis | Poor | <1% |
