Electron microscopy of cardiomyocytes in hydroxychloroquine cardiomyopathy

The EM at 17600x magnification shows sarcomere drop out (between thick arrows) caused by proliferation of lysosomes that are at various stages of condensation. The arrowhead points to a lysosome with a single membrane prior to condensation. The thin yellow arrow points to a lysosome with lamellated membrane structures that has undergone condensation.