Disease | Aim of treatment | Example of treatment |
AA amyloidosis | Suppress the acute phase response and thereby reduce the production of serum amyloid A protein | Anti-inflammatory and immunosuppressive therapy in patients with rheumatoid arthritis and Crohn disease (eg, anti-TNF antibodies, humanized anti-IL6 receptor antibody) Colchicine for patients with familial Mediterranean fever Surgery for patients with osteomyelitis and rare cytokine-producing tumors |
AL amyloidosis | Suppress production of monoclonal immunoglobulin light chains | Chemotherapy directed at plasma cell dyscrasia |
Hereditary amyloidosis | Eliminate source of genetically variant protein | Orthotopic liver transplantation for patients with familial amyloid polyneuropathy secondary to variant transthyretin or renal amyloidosis secondary to variant fibrinogen A α-chain |
β2-microglobulin amyloidosis | Reduce plasma concentration of β2-microglobulin | Renal transplantation |