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Calculator: International Prognostic Index for non-Hodgkin lymphoma in adults


Calculator: International Prognostic Index for non-Hodgkin lymphoma in adults

 

Age >60 years old (1 point)

Serum lactate dehydrogenase concentration above normal (1 point)

Ann Arbor stage III or IV (1 point)

More than one extranodal disease site (1 point)
ECOG performance scale

Performance status 0: Fully active; no performance restrictions (0 points)

Performance status 1: Strenuous physical activity restricted; fully ambulatory and able to carry out light work (0 points)

Performance status 2: Capable of all self-care but unable to carry out any work activities. Up and about >50% of waking hours (1 point)

Performance status 3: Capable of only limited self-care; confined to bed or chair >50% of waking hours (1 point)

Performance status 4: Completely disabled; cannot carry out any self-care; totally confined to bed or chair (1 point)

 
Important: Inputs must be complete to perform calculation.

 
Total criteria point count:
 

 

When applied to a group of 2031 patients with aggressive non-Hodgkin lymphoma treated with anthracycline-based regimens that did NOT include rituximab, 5-year overall survival (OS) and complete response (CR) rates were as follows:

 
0 to 1 point: Low risk with 73% 5-year OS and 87% CR
2 points: Low-intermediate risk with 51% 5-year OS and 67% CR
3 points: High-intermediate risk with 43% 5-year OS and 55% CR
4 to 5 points: High risk with 26% 5-year OS and 44% CR

 

 

When applied to 1063 patients treated with rituximab plus CHOP/CHOP-like chemotherapy, 3-year event-free survival (EFS), progression-free survival (PFS), and overall survival (OS) were as follows:

 
0 to 1 point: EFS 81%, PFS 87%, and OS 91%
2 points: EFS 69%, PFS 75%, and OS 81%
3 points: EFS 53%, PFS 59%, and OS 65%
4 to 5 points: EFS 50%, PFS 50%, and OS 59%

 
Notes
  • ECOG: Eastern Cooperative Oncology Group; NHL: Non-Hodgkin lymphoma.

 
Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

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