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Rates of cutaneous reactions to drugs

Rates of cutaneous reactions to drugs
Drug Rate (%) of allergic cutaneous reactions
Amoxicillin 1.2 to 5.1
Ampicillin 3.3
Trimethoprim-sulfamethoxazole 2.1 to 3.4
Semisynthetic penicillins 2.1
Penicillin G 1.9
Cephalosporins 1.5
Erythromycin 2.0
Gentamicin 0.5
Doxycycline 0.5
Fluoroquinolones 0.1 to 1.6
Furosemide 0.05
Allopurinol 0.8
Metoclopramide 0.3
Heparin sodium 0.1
Barbiturates 0.4
Nitrazepam 0.2
Diazepam 0.04
Lamotrigine 0.6
Carbamazepine 0.3
Maprotiline 0.2
Escitalopram 0.2
Tricyclic/tetracyclic antidepressants 0.07
SSRIs 0.05
SSRI: selective serotonin reuptake inhibitor.
References:
  1. Bigby M, Jick S, Jick H, Arndt K. Drug-induced cutaneous reactions. A report from the Boston Collaborative Drug Surveillance Program on 15,438 consecutive inpatients, 1975 to 1982. JAMA 1986; 256:3358.
  2. van der Linden PD, van der Lei J, Vlug AE, Stricker BH. Skin reactions to antibacterial agents in general practice. J Clin Epidemiol 1998; 51:703.
  3. Kulthanan K, Chularojanamontri L, Manapajon A, et al. Cutaneous adverse reactions to fluoroquinolones. Dermatitis 2011; 22:155.
  4. Lange-Asschenfeldt C, Grohmann R, Lange-Asschenfeldt B, et al. Cutaneous adverse reactions to psychotropic drugs: data from a multicenter surveillance program. J Clin Psychiatry 2009; 70:1258.
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