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Interactions between antiseizure medications and cytotoxic drugs

Interactions between antiseizure medications and cytotoxic drugs
ASM CTDs that decrease ASM concentration CTDs that increase ASM concentration CTDs whose concentrations are lowered by ASM CTDs whose toxicity is increased by ASM
Phenytoin

Nitrosourea

Cisplatin

Etoposide

Dacarbazine

Doxorubicin

Carboplatin

Vinblastine

Methotrexate

Bleomycin

Dexamethasone

5-FU

Tegafur

Tamoxifen

Busulfan

Vincristine

Methotrexate

Paclitaxel

Topotecan

Irinotecan

9-Aminocampthotecin

Teniposide

Dexamethasone
 
Carbamazepine

Cisplatin

Doxorubicin
 

Vincristine

Methotrexate

Paclitaxel

9-Aminocampthotecin

Teniposide
 
Valproic acid

Methotrexate

Cisplatin

Doxorubicin
   

Nitrosoureas

Cisplatin

Etoposide
Phenobarbital    

Thiotepa

Nitrosoureas

Vincristine

Methotrexate

Paclitaxel

9-Aminocampthotecin

Teniposide

Procarbazine

Prednisone
 
ASM: antiseizure medications; CTD: cytotoxic drugs.
Adapted from: DeAngelis LM, Posner JB, Neurologic Complications of Cancer, 2nd, Oxford University Press, New York, 2009; by permission of Oxford University Press, Inc. www.oup.com. Copyright © 2009.
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