Skin bleaching: Topical: Apply a thin layer to the affected areas and rub in well twice daily, in the morning and at bedtime Discontinue use if no improvement is seen after 2 to 3 months of treatment.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Skin bleaching: Children ≥12 years and Adolescents: Refer to adult dosing.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Cream, External:
AMBI Fade: 2% (56 g [DSC]) [contains cetyl alcohol, disodium edta, ethylparaben, methylparaben, propylparaben, sodium metabisulfite, soy protein, soya sterol]
Blanche: 4% (30 g) [contains cetearyl alcohol, disodium edta, sodium metabisulfite]
EpiQuin Micro: 4% (30 g [DSC]) [contains benzyl alcohol, methylparaben, sodium metabisulfite, trolamine (triethanolamine), vitamin a (retinol), vitamin e (vit e)]
Esoterica Daytime: 2% (70 g [DSC]) [contains disodium edta, methylparaben, propylene glycol, propylparaben, sodium bisulfite]
Esoterica Daytime: 2% (70 g [DSC]) [contains disodium edta, methylparaben, propylene glycol, propylparaben, sodium metabisulfite]
Esoterica Fade Nighttime: 2% (70 g [DSC]) [contains disodium edta, methylparaben, propylene glycol, propylparaben, sodium metabisulfite]
Hydroquinone Time Release: 4% (30 g [DSC]) [contains benzyl alcohol, cetyl alcohol, edetate (edta) disodium, sodium metabisulfite, trolamine (triethanolamine)]
Remergent HQ: 4% (30 mL [DSC]) [contains sodium metabisulfite]
TL Hydroquinone: 4% (30 g [DSC]) [contains benzyl alcohol, cetearyl alcohol, cetyl alcohol, edetate (edta) disodium, methylparaben, sodium metabisulfite, trolamine (triethanolamine)]
Generic: 4% (28.35 g, 28.4 g)
Gel, External:
NeoStrata HQ Skin Lightening: 2% (30 g [DSC]) [fragrance free, oil free; contains propylene glycol, sodium bisulfite, sodium sulfite]
May be product dependent
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Cream, External:
Drula Fade Superforte Medicate: 4-4 GM/100GM ([DSC])
Nuderm Sunfader: 7.5-4-5.5 % ([DSC])
Generic: 4% ([DSC])
Gel, External:
Seequin 4 IDs: 4% ([DSC])
Generic: 4% (30 g)
For external use only; avoid contact with eyes and mucous membranes. Apply a thin layer using fingertips to the affected areas and rub in well. Avoid sun exposure during treatment and maintenance therapy by using a broad spectrum sunscreen (SPF 15 or greater) or protective clothing.
Topical: For external use only; avoid contact with eyes and mucous membranes. Shake solution prior to use. Wash and pat dry affected area prior to application. Apply a thin layer using fingertips to the affected areas and rub in well. Avoid sun exposure during treatment and maintenance therapy by using a broad spectrum sunscreen (SPF 15 or greater) or protective clothing.
Skin bleaching: Gradual bleaching of hyperpigmented skin conditions, such as chloasma, melasma, freckles, senile lentigines, and other unwanted areas of melanin hyperpigmentation
Eldopaque may be confused with Eldoquin
Eldopaque Forte may be confused with Eldoquin Forte
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.
Dermatologic: Allergic skin reaction, dermatitis, erythema, inflammation, stinging of the skin, xeroderma
Local: Local irritation
Hypersensitivity to hydroquinone or any component of the formulation
Other warnings/precautions:
• Appropriate use: Limit application to area no larger than face and neck or hands and arms.
None known.
There are no known significant interactions.
Animal reproduction studies have not been conducted with topical administration; the amount of systemic absorption is unknown.
It is not known if hydroquinone is excreted in breast milk. The manufacturer recommends that caution be exercised when administering hydroquinone to nursing women
Produces reversible depigmentation of the skin by suppression of melanocyte metabolic processes, in particular the inhibition of the enzymatic oxidation of tyrosine to DOPA (3,4-dihydroxyphenylalanine); sun exposure reverses this effect and will cause repigmentation.
Onset and duration of depigmentation produced by hydroquinone varies among individuals
Cream (Blanche External)
4% (per gram): $2.60
Cream (Hydroquinone External)
4% (per gram): $2.56 - $3.77
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