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Types of drug reactions associated with eosinophilia

Types of drug reactions associated with eosinophilia
Manifestations Commonly associated drugs
Asymptomatic Penicillins, cephalosporins
Soft tissue swelling GM-CSF, IL-2
Pulmonary infiltrates NSAIDs
Interstitial nephritis Semisynthetic penicillins, cephalosporins, NSAIDs
Myocarditis Ranitidine
Hepatitis Semisynthetic penicillins, tetracyclines
Hypersensitivity vasculitis Allopurinol, phenytoin
Gastroenterocolitis NSAIDs
Asthma, nasal polyps Aspirin
Eosinophilia-myalgia syndrome L-tryptophan contaminant
DRESS Sulfasalazine, phenytoin, carbamazepine, allopurinol, hydrochlorothiazide, cyclosporine, nevirapine
GM-CSF: granulocyte-macrophage colony-stimulating factor; IL-2: interleukin-2; NSAIDs: nonsteroidal antiinflammatory drugs; DRESS: drug reaction with eosinophilia and systemic symptoms.
Original figure modified for this publication. Mejia R, Nutman TB. Evaluation and differential diagnosis of marked, persistent eosinophilia. Semin Hematol 2012; 49:149. Table used with the permission of Elsevier Inc. All rights reserved.
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