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Uptodate Reference Title
Mechanisms for urate secretion by the proximal tubule
Mechanisms for urate secretion by the proximal tubule
Urate enters the cell at the basolateral membrane via exchange with alpha-ketoglutarate, mediated by OAT1 and OAT3. At the apical membrane, urate is secreted via MRP4, ABCG2, NPT1, and/or NPT4.
Courtesy of David B Mount, MD, 2012. Updated with information from:
Johnson RJ, Bakris GL, Borghi C, et al. Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney Foundation. Am J Kidney Dis 2018; 71:851.
Mandal AK, Mount DB. The molecular physiology of uric acid homeostasis. Annu Rev Physiol 2015; 77:323.
