your limit has been reached. plz Donate us to allow your ip full access, Email: sshnevis@outlook.com

Clinical features distinguishing type 1 diabetes, type 2 diabetes, and monogenic diabetes*

Clinical features	Type 1 diabetes mellitus	Type 2 diabetes mellitus	Monogenic diabetes
Age of diagnosis (years)	Majority <25, but may occur at any age	Typically >25 but incidence is increasing in adolescents, paralleling increasing rates of obesity in children and adolescents^¶	<25
Weight	Usually thin, but with obesity epidemic overweight and obesity at diagnosis becoming more common	>90% at least overweight	Similar to general population
Autoantibodies	Present	Absent	Absent
Insulin dependent	Yes	No	No
Insulin sensitivity	Normal when controlled	Decreased	Normal (may be decreased if obese)
Family history of diabetes	Infrequent (5 to 10%)	Frequent (75 to 90%)	Multigenerational, ie, ≥3 generations
Risk of diabetic ketoacidosis	High	Low	Low

* Formerly called maturity onset diabetes of the young (MODY).
¶ In North America, type 2 diabetes predominates in Hispanic American, African American, Native American, Canadian First Nation, Pacific Islander, and Asian American youth.

Data from:

Naylor R, Philipson LH. Who should have genetic testing for maturity-onset diabetes of the young? Clin Endocrinol (Oxf) 2011; 75:422.
Ramesh SC, Marshall I. Clinical Suspicion of Maturity Onset of Diabetes of the Young in Pediatric Patients Diagnosed with Diabetes Mellitus. Indian J Pediatr 2012; 79:955.
Thanabalasingham G, Owen KR. Diagnosis and management of maturity onset diabetes of the young (MODY). BMJ 2011; 343:d6044.
Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr 2005; 146:693.
De Ferranti SD, Osganian SK. Epidemiology of paediatric metabolic syndrome and type 2 diabetes mellitus. Diab Vasc Dis Res 2007; 4:285.

Graphic 83072 Version 5.0