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Uptodate Reference Title
Peripheral smear from a patient with the typical hypergranular type of acute promyelocytic leukemia (APL)
Peripheral smear from a patient with the typical hypergranular type of acute promyelocytic leukemia (APL)
The white cell count in this type of APL is usually low with only a few circulating malignant promyelocytes. The abnormal promyelocytes frequently have bi-lobed or dumbbell shaped nuclei with granular cytoplasm. They can be difficult to recognize due to their scarcity, but when seen they should immediately raise the possibility of APL.