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Cross-reactivity between penicillins and cephalosporins with identical side chains

Cross-reactivity between penicillins and cephalosporins with identical side chains
Study Selective allergy to Cephalosporin with identical side chain Reaction rate (%)
Audicana (1994)[1] Ampicillin Cephalexin 1 of 10 (10)
Sastre (1996)[2] Amoxicillin Cefadroxil 2 of 16 (12)
Miranda (1996)[3] Amoxicillin Cefadroxil 8 of 21 (38)
Total     11 of 47 (23)
Amoxicillin and ampicillin are aminopenicillins. This table provides a summary of studies in which patients proven to be selectively allergic to amoxicillin or ampicillin were challenged with cephalosporins containing identical R1 side chains.
References:
  1. Audicana M, Bernaola G, Urrutia I, et al. Allergic reactions to betalactams: studies in a group of patients allergic to penicillin and evaluation of cross-reactivity with cephalosporin. Allergy 1994; 49:108.
  2. Sastre J, Quijano LD, Novalbos A, et al. Clinical cross-reactivity between amoxicillin and cephadroxil in patients allergic to amoxicillin and with good tolerance of penicillin. Allergy 1996; 51:383.
  3. Miranda A, Blanca M, Vega JM, et al. Cross-reactivity between a penicillin and a cephalosporin with the same side chain. J Allergy Clin Immunol 1996; 98:671.
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