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Muscle histochemistry from a patient with a mitochondrial disorder
Muscle histochemistry from a patient with a mitochondrial disorder
(A) Succinate dehydrogenase (SDH) stain shows mitochondrial proliferation ("ragged-blue" fibers) and strongly SDH-reactive vessels (SSVs; arrow).
(B) Cytochrome c oxidase (COX) stain shows reduced enzyme activity in individual fibers (asterisk) and a COX-negative SSV (arrow); x20.
Reproduced with permission from: Mancuso M, Filosto M, Mootha VK, et al. A novel mitochondrial tRNAPhe mutation causes MERRF syndrome. Neurology 2004; 62:2119. Copyright © 2004 Lippincott Williams & Wilkins.
Graphic 82373 Version 6.0
