| Indication |
| High-risk (massive) PE (ie, presence of hypotension related to PE)* |
| Potential indication |
| Patients with severe right ventricular dysfunction due to PE (ie, intermediate risk PE) |
| Others: |
| Presence of severe hypoxemia (particularly in those with a contribution from concomitant cardiopulmonary disease) |
| Patients with acute PE who appear to be decompensating but are not yet hypotensive |
| Extensive clot burden |
