| | Cutaneous features | Systemic features |
| Common | Erythematous urticarial papules and plaques (wheals), angioedema, dermographism, annular erythema | Musculoskeletal: arthralgia, arthritis |
| Less common | Urticarial lesions with residual hyperpigmentation and/or purpura | Respiratory: cough, dyspnea, hemoptysis, COPD, asthma, pleural effusion
|
| Renal disease: proteinuria, hematuria, glomerulonephritis |
| Gastrointestinal: substernal pain, abdominal pain, nausea, vomiting, diarrhea |
| Rare | Erythema multiforme-like lesions, livedo reticularis, Raynaud's phenomenon, laryngeal edema | Cardiac: pericarditis, pericardial effusion, cardiac tamponade |
| Ophthalmologic: conjunctivitis, episcleritis, uveitis, geographic serpiginous choroidopathy, visual loss |
| Other: fever, splenomegaly, lymphadenopathy, cold sensitivity, reversible tracheal stenosis |
| Very rare | | CNS: pseudotumor cerebri, cranial nerve palsies, aseptic meningitis |
| Miscellaneous: transverse myelitis, cardiac valve disease, optic atrophy, Jaccoud's arthropathy (chronic non-erosive, deforming arthropathy), peripheral neuropathy, pleuritis |
