| G6PD risk* | Description |
Systemic agents¶ |
Sulfadiazine | Low | As single agent or in combination with pyrimethamine |
Sulfadoxine | | As single agent or in combination with pyrimethamine; long-acting◊ |
SulfaguanidineΔ | Low | Gastrointestinal antimicrobial |
SulfamerazineΔ | Low | In combination with other sulfonamides or trimethoprim |
SulfamethizoleΔ | | Urinary tract antimicrobial |
Sulfamethazine (sulfadimidine)Δ | High | As single agent or in combination with other sulfonamides |
Sulfamethoxazole | Variable | In combination with trimethoprim or as single agent |
SulfametopyrazineΔ | | In combination with pyrimethamine; long-acting◊ |
SulfamoxoleΔ | | In combination with trimethoprim |
SulfapyridineΔ | | Rarely used due to crystalluria risk |
Sulfasalazine (salazosulfapyridine, salazopyrin) | High | Rheumatologic/gastrointestinal agent (nonantimicrobial); releases sulfapyridine in contact with gut flora |
Sulfisoxazole (sulfafurazole) | High | As single agent or in combination with erythromycin |
Topical and ophthalmic agents |
Mafenide | | Topical solution or cream |
Silver sulfadiazine | Low | Topical cream or ointment |
Sulfacetamide | High | As single agent ophthalmic solution, ointment, various topicals, vaginal or in combination with sulfabenzamide, sulfathiazole, or prednisolone |
Sulfanilamide | High | As single agent vaginal or in combination with other antimicrobials |