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Hypothetical model for the pathogenesis of the end-stage phase of hypertrophic cardiomyopathy with left ventricular wall thinning and cavity enlargement

Hypothetical model for the pathogenesis of the end-stage phase of hypertrophic cardiomyopathy with left ventricular wall thinning and cavity enlargement
LV: left ventricular.
* Indicates the following possibilities: 1) enhanced myocardial oxygen requirements and reduced myocardial capillary density relative to marked left ventricular hypertrophy (LVH); and 2) increased diastolic wall tension and coronary vascular resistance resulting from abnormal LV relaxation and impaired filling.
Redrawn from Maron BJ, Spirito P, Am J Cardiol 1998; 81:1339.
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