| Inherited enzyme defects leading to purine overproduction (rare monogenic disorders) |
| Hypoxanthine-guanine phosphoribosyltransferase deficiency |
| Phosphoribosylpyrophosphate synthetase overactivity |
| Glucose-6-phosphatase deficiency (glycogen storage disease, type I) |
| Clinical disorders leading to purine and/or urate overproduction |
| Myeloproliferative disorders |
| Lymphoproliferative disorders |
| Hemolytic disorders |
| Psoriasis |
| Tissue hypoxia |
| Down syndrome |
| Glycogen storage diseases (types III, V, VII) |
| Drug- and diet-induced purine and/or urate overproduction |
| Excessive ethanol ingestion |
| Excessive dietary purine ingestion |
| Excessive fructose ingestion |
| Cytotoxic drugs |
