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Commonly used chemotherapy combinations for patients with soft tissue sarcoma

Commonly used chemotherapy combinations for patients with soft tissue sarcoma
Regimen Drug Dose (total per cycle) Schedule
AI
LeCesne A; 2000 Doxorubicin 50 or 75 mg/m2 day 1 (50 to 75 mg/m2) Every 3 weeks
Ifosfamide* 5 g/m2 over 24 hours, day 1 (5 g/m2)
Mesna 2.5 g/m2 mixed with ifosfamide IV over 24 hours; 1.25 g/m2 IV over 12 hours after ifosfamide
Worden F; 2005 Doxorubicin 20 mg/m2 days 1, 2, 3 (60 mg/m2) Every 3 weeks, G-CSF
Ifosfamide* 1.5 g/m2 over 2 hours, days 1 through 4 (6 g/m2)
Mesna 225 mg/m2 IV over 1 hour before ifosfamide, 4 and 8 hours after ifosfamide; G-CSF 5 mcg/kg per day, once daily for 10 days, start on day 5
Patel S; 1998 Doxorubicin 25 mg/m2 over 24 hours, days 1, 2, 3 (75 mg/m2) Every 3 weeks, G-CSF
Ifosfamide* 2 g/m2 over 2 hours, days 1 through 5 (10 g/m2)
Mesna 400 mg/m2 with first dose ifosfamide, then start 1200 mg/m2 over 24 hours per day, for 5 days
Epirubicin/ifosfamide
Palumbo R; 1999 Epirubicin 55 mg/m2 start IV bolus, days 1, 2 (110 mg/m2) Every 3 weeks, G-CSF
Ifosfamide* 2.5 g/m2 over 24 hours, days 1 through 4 (10 g/m2)
Mesna 2.5 g/m2 over 24 hours, days 1 through 5
AD
Antman K; 1993 Doxorubicin 15 mg/m2 over 24 hours, days 1 through 4 (60 mg/m2) Every 3 weeks
Dacarbazine 250 mg/m2 over 24 hours, days 1 through 4 (1000 mg/m2)
MAID
Antman K; 1993, 1998 Doxorubicin 15 mg/m2 over 24 hours, days 1 through 4 Every 3 weeks
Ifosfamide* 2 g/m2 over 24 hours, days 1 through 3
Dacarbazine 250 mg/m2 over 24 hours, days 1 through 4 (mix with doxorubicin)
Mesna 2.5 g/m2 over 24 hours, days 1 through 4
DeLaney T; 2003 Doxorubicin 20 mg/m2 over 24 hours, days 1 through 3 Every 3 weeks
Ifosfamide* 2 g/m2 over 24 hours, days 1 through 3
Dacarbazine 250 mg/m2 over 24 hours, days 1 through 4 (mix with doxorubicin)
Mesna 2.5 g/m2 over 24 hours, days 1 through 4
Gemcitabine/docetaxel
Leu K; 2004 Gemcitabine 675 mg/m2 days 1 and 8 Every 3 weeks
Docetaxel 100 mg/m2 day 8
Hensley M; 2002 Gemcitabine 900 mg/m2 days 1 and 8 (675 mg/m2 days 1 and 8Δ) Every 3 weeks, G-CSF
Docetaxel 100 mg/m2 day 8 (75 mg/m2 day 8Δ)
Gemcitabine/vinorelbine
Dileo P; 2007 Vinorelbine 25 mg/m2 over 10 minutes, days 1 and 8 Every 3 weeks
Gemcitabine 800 mg/m2 over 90 minutes, days 1 and 8
Gemcitabine/dacarbazine
Garcia-del Muro X; 2011 Gemcitabine 1800 mg/m2 given by fixed rate infusion (10 mg/m2 per minute), day 1 Every 2 weeks
Dacarbazine 500 mg/m2 day 1
G-CSF: granulocyte colony-stimulating factor.
* With Mesna.
¶ With routine G-CSF support.
Δ Lower doses (gemcitabine 675 mg/m2, docetaxel 75 mg/m2) administered to previously irradiated patients.
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