Regimen | Drug | Dose (total per cycle) | Schedule |
AI |
LeCesne A; 2000 | Doxorubicin | 50 or 75 mg/m2 day 1 (50 to 75 mg/m2) | Every 3 weeks |
Ifosfamide* | 5 g/m2 over 24 hours, day 1 (5 g/m2) |
Mesna | 2.5 g/m2 mixed with ifosfamide IV over 24 hours; 1.25 g/m2 IV over 12 hours after ifosfamide¶ |
Worden F; 2005 | Doxorubicin | 20 mg/m2 days 1, 2, 3 (60 mg/m2) | Every 3 weeks, G-CSF¶ |
Ifosfamide* | 1.5 g/m2 over 2 hours, days 1 through 4 (6 g/m2) |
Mesna | 225 mg/m2 IV over 1 hour before ifosfamide, 4 and 8 hours after ifosfamide; G-CSF 5 mcg/kg per day, once daily for 10 days, start on day 5 |
Patel S; 1998 | Doxorubicin | 25 mg/m2 over 24 hours, days 1, 2, 3 (75 mg/m2) | Every 3 weeks, G-CSF¶ |
Ifosfamide* | 2 g/m2 over 2 hours, days 1 through 5 (10 g/m2) |
Mesna | 400 mg/m2 with first dose ifosfamide, then start 1200 mg/m2 over 24 hours per day, for 5 days |
Epirubicin/ifosfamide |
Palumbo R; 1999 | Epirubicin | 55 mg/m2 start IV bolus, days 1, 2 (110 mg/m2) | Every 3 weeks, G-CSF¶ |
Ifosfamide* | 2.5 g/m2 over 24 hours, days 1 through 4 (10 g/m2) |
Mesna | 2.5 g/m2 over 24 hours, days 1 through 5 |
AD |
Antman K; 1993 | Doxorubicin | 15 mg/m2 over 24 hours, days 1 through 4 (60 mg/m2) | Every 3 weeks |
Dacarbazine | 250 mg/m2 over 24 hours, days 1 through 4 (1000 mg/m2) |
MAID |
Antman K; 1993, 1998 | Doxorubicin | 15 mg/m2 over 24 hours, days 1 through 4 | Every 3 weeks |
Ifosfamide* | 2 g/m2 over 24 hours, days 1 through 3 |
Dacarbazine | 250 mg/m2 over 24 hours, days 1 through 4 (mix with doxorubicin) |
Mesna | 2.5 g/m2 over 24 hours, days 1 through 4 |
DeLaney T; 2003 | Doxorubicin | 20 mg/m2 over 24 hours, days 1 through 3 | Every 3 weeks |
Ifosfamide* | 2 g/m2 over 24 hours, days 1 through 3 |
Dacarbazine | 250 mg/m2 over 24 hours, days 1 through 4 (mix with doxorubicin) |
Mesna | 2.5 g/m2 over 24 hours, days 1 through 4 |
Gemcitabine/docetaxel |
Leu K; 2004 | Gemcitabine | 675 mg/m2 days 1 and 8 | Every 3 weeks |
Docetaxel | 100 mg/m2 day 8 |
Hensley M; 2002 | Gemcitabine | 900 mg/m2 days 1 and 8 (675 mg/m2 days 1 and 8Δ) | Every 3 weeks, G-CSF |
Docetaxel | 100 mg/m2 day 8 (75 mg/m2 day 8Δ) |
Gemcitabine/vinorelbine |
Dileo P; 2007 | Vinorelbine | 25 mg/m2 over 10 minutes, days 1 and 8 | Every 3 weeks |
Gemcitabine | 800 mg/m2 over 90 minutes, days 1 and 8 |
Gemcitabine/dacarbazine |
Garcia-del Muro X; 2011 | Gemcitabine | 1800 mg/m2 given by fixed rate infusion (10 mg/m2 per minute), day 1 | Every 2 weeks |
Dacarbazine | 500 mg/m2 day 1 |