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Clinical designation of genital herpes simplex virus infection (HSV)

Direct viral test result*	Type-specific serologic status^¶		Classification of genital HSV infection
Direct viral test result*	HSV-1 antibodies	HSV-2 antibodies	Classification of genital HSV infection
HSV-1 detected	–	–	Primary HSV-1 infection
	–	+	Nonprimary first episode HSV-1 infection^Δ
	+	– or +	Recurrent HSV-1 infection
HSV-2 detected	–	–	Primary HSV-2 infection
	+	–	Nonprimary first episode HSV-2 infection
	– or +	+	Recurrent HSV-2 infection

* Testing of the ulcerative lesion with culture, polymerase chain reaction, or direct fluorescent antibody.
¶ Performed at the time of initial presentation with the ulcerative lesion.
Δ Nonprimary first episode genital HSV-1 infection is rare.

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