Association of type 1 diabetes with diabetogenic genes
Association of type 1 diabetes with diabetogenic genes
Direct correlation in different populations between the gene frequency of "diabetogenic" HLA-DQbeta genotypes (which lack aspartate at position 57 on the beta chain) and the predicted and observed incidence of type 1 diabetes mellitus (per 100,000 population).
Data from: Dorman JS, LaPorte RE, Stone RA, Trucco M, Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain. Proc Natl Acad Sci USA 1990; 87:7370.
