| Goals | |
| Lifestyle risk factors | |
| Abdominal obesity | Year 1: Reduce body weight 7 to 10 percent |
| Continue weight loss thereafter with ultimate goal BMI <25 kg/m2 | |
| Physical inactivity | At least 30 min (and preferably ≥60 min) continuous or intermittent moderate intensity exercise 5 times per week, but preferably daily |
| Atherogenic diet | Reduced intake saturate fat, trans fat, cholesterol |
| Metabolic risk factors | |
| Dyslipidemia | |
| Primary target elevated LDL cholesterol | High risk*: <100 mg/dL (2.6 mmol/>L); optional <70 mg/dL |
| Moderate risk: <130 mg/dL (3.4 mmol/L) | |
| Lower risk: <160 mg/dL (4.9 mmol/L) | |
| Secondary target elevated non-HDL cholesterol | High risk*: <130 mg/dL (3.4 mmol/L); optional <100 mg/dL (2.6 mmol/L) very high risk |
| Moderate risk: <160 mg/dL (4.1 mmol/L) | |
| Lower risk: <190 mg/dL (4.9 mmol/L) | |
| Tertiary target reduced HDL cholesterol | Raise to extent possible with weight reduction and exercise |
| Elevated blood pressure | Reduce to at least <140/90 (<130/80 if diabetic) |
| Elevated glucose | For IFG, encourage weight reduction and exercise |
| For type 2 DM, target A1C <7 percent | |
| Prothrombotic state | Low-dose aspirin for high-risk patients |
| Proinflammatory state | Lifestyle therapies; no specific interventions |
