| Disease | Transport abnormality |
| Sickle cell syndromes | Cellular dehydration mediated by increases in K-Cl cotransport and activity of the calcium-activated (Gardos) potassium channel |
| Beta thalassemia | Relative cellular dehydration mediated by K-Cl cotransport |
| Hemoglobin C disease | Cellular dehydration mediated by increased K-Cl cotransport |
| Hereditary spherocytosis | Increased sodium and potassium permeability |
| Hereditary stomatocytosis | Hyperhydration due to increased sodium permeability or dehydration (xerocytosis) associated with enhanced potassium loss |
